Strain history – sboulardii

The Saccharomyces boulardii CNCM I-745 story began in the jungles of South East Asia…

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In 1923¹, while on an expedition in South East Asia, the French microbiologist Henri Boulard made a chance discovery. He observed locals drinking a concoction made from the skins of two tropical fruits, litchis and mangosteens, to relieve stomach problems, including diarrhea.^2,3

The special ingredient in this anti-diarrheal remedy was found to be a single yeast strain and Henri Boulard called it Saccharomyces boulardii.²

Image of the single strain probiotic yeast Saccharomyces boulardii CNCM I-745 and the tropical fruits (litchi and mangosteen) the yeast was isolated

Figure 1 : The yeast probiotic Saccharomyces boulardii CNCM I-745 was isolated from mangosteen and litchi tropical fruit skins² in 1923¹.
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This yeast is unique in the fact that it is from the Saccharomyces cerevisiae family but displays properties that separate it from S. Cerevisiae.³It is some of these unique properties make it well suited to be a probiotic, including a tolerance of acid and the fact that it grows at 37°C (human body temperature).³

S. boulardii CNCM I-745 is the first yeast to be demonstrated to have probiotic properties and the first probiotic in human medicine.² The yeast has been investigated in more than 100clinical trials and has been available as a probiotic treatment for diarrhea for over 56 years!

Almost 460 million people have been treated with the unique strain Saccharomyces boulardii CNCM I-745 since the 1980s, and it is used in more than 90 countries.

image https://www.saccharomycesboulardii.com/wp-content/uploads/2020/06/sboulardii-CNCM-I-745-history-150x150.png

Figure 2 : The key numbers for the unique single-strain yeast probiotic Saccharomyces boulardii CNCM I-745.
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Since it was discovered and then used as a probiotic drug , S. boulardii CNCM I-745 has been used to treat, prevent and recover from diarrhea.² S. boulardii CNCM I-745 also creates a favourable growth environment for the beneficial gut microbiota after an imbalance created by diarrhea.^1,^*

Saccharomyces boulardii CNCM I-745 is a probiotic with a unique and long history whose story continues to this very day!

*The prescribed usage of Saccharomyces boulardii CNCM I-745 for different conditions varies country to country. Please refer to your local Product Information, or speak with your doctor or pharmacist.

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References

01 . More MI, and Swidsinski, A. Saccharomyces boulardii CNCM I-745 supports regeneration of the intestinal microbiota after diarrheic dysbiosis–a review. Clinical and experimental gastroenterology. 2015; 8: 237.
02 . Joly, F et al. 2017. Saccharomyces boulardii CNCM I-745. Marteau, P and Dore J (Ed.), Gut Microbiota: A full-fledged organ. 2017: 305-326. Paris: John Libbey Eurotext.
03 . Czerucka, D., T. Piche, and P. Rampal. Yeast as probiotics–Saccharomyces boulardii. Alimentary pharmacology & therapeutics. 2007; 26(6): 767-778.